Kill the Runebear boss
To complete this square you need to defeat Runebear, the boss in the Earthbore Cave. Wait until the "ENEMY DEFEATED" or equivalent screen appears to mark the square.
This square has synergies for Acquire 4 Talismans with ‘Drake’ in the name (Runebear drops the Spelldrake Talisman) and Complete 3 cave or grotto dungeons.
Runebear counts as a Limgrave/Weeping Peninsula boss.