Kill Ensha
To complete this square you need to defeat Ensha, the NPC who attacks you in Roundtable Hold. Wait until the "ENEMY DEFEATED" or equivalent screen appears to mark the square.
To access the fight against Ensha, you need to obtain the Haligtree Medalion half from Albus at the Village of Albinaurics and then port to Roundtable Hold. This square has geographic synergy with Kill an Omenkiller.
DANGER
Ensha does not count as a NPC invader and does not count as a boss. He is a standalone fight.