Finish off a boss with the explosive Physick
This square requires you to use the Ruptured Crystal Tear to deplete any boss HP to zero, regardless of how much damage from other sources you deal. The final blow needs to be the explosion caused by using the Physick Flask when charged with the Ruptured Crystal Tear.
There are synergies with Acquire 10 Physick Flask tears, Kill 3 Erdtree/Putrid Avatars (to obtain the Crystal Tear you need to kill one of Liurnia's Erdtree Avatar bosses), and any other square that requires killing a boss.
You do not need to survive the explosion to mark the square. Only the boss kill and obtaining its rewards is required.